CSF1R (colony stimulating factor 1 receptor) is a membrane-integrated tyrosine kinase receptor expressed by monocytes, macrophages, and other cells of the myeloid lineage. CSF1R is a key factor in the tumorpermissive and immunosuppressive behaviour of ‘tumor associated macrophages’ by promoting tumor progression and survival via suppressing effector T-cell functions. Known translocation partner genes involved in CSF1R rearrangements, identified in Ph-like cases, are SSBP2, MEF2D and TBL1XR1.
- Sample collection: Tumour Tissue Block
- Specimen preparation: Do not freeze or expose to extreme temperatures.
- FFPE Tissue Block: Formalin fix (10 percent neutral buffered formalin) and paraffin-embed tissue (3–4-micron thick sections in positively charged/silanized slides). Fixative duration: 6-48 hours.
- Storage/Transport Temperature: Room temperature.
- Unacceptable Conditions: Paraffin block with no tumor tissue remaining. Specimens fixed in any fixative other than 10 percent neutral buffered formalin. Decalcified specimens. Specimens with fixation delayed for more than one hour. Tissue fixed or less than 6 hours of greater than 48 hours.
- Remarks:
- Stability: Ambient: Indefinitely; Refrigerated: Indefinitely; Frozen: Unacceptable
Fluorescence in situ Hybridization (FISH)
Sample received to report Turnaround time (TAT)
3 working days
————-
Interpretive Data
The most recent WHO classification of Tumours of Hematopoietic and Lymphoid Tissues (Revised 5th edition) is used for interpretation criteria for evaluation.
Resources
- Additional Technical Information
- Test Request Form
Sample Reports
- Enhanced Report
- See report