VKORC1 and CYP2C9 polymorphism

Intended Use: To identify individuals with inherited gene variants that affect dose requirements for warfarin.

Specimen Required: Lavender (EDTA), Pink (K2EDTA)

Patient Preparation 

• Sample Collection: 2 Tubes / EDTA Blood / 2 mL per tube
• Specimen Preparation: Do not freeze. Transport 3 mL whole blood. (Min: 1 mL)
• Storage/Transport Temperature: Refrigerated
• Unacceptable Conditions
  • Plasma or serum.
  • Heparinized specimens.
  • Frozen specimens in glass collection tubes.

• Remarks: –
• Stability: Ambient: 72 hours; Refrigerated: 1 week; Frozen: 1 month.

Methodology: This test utilizes a multiplex real-time PCR to amplify and detect single nucleotide polymorphisms in the VKORC1 and CYP2C9 genes for genotype discrimination.

Sample Received to Report Turnaround Time (TAT): Twice in a week (Scheduled test)

Reference Interval: –

Interpretive Data: Refer to report