Aids in risk stratification of individuals with plasma cell neoplasms (monoclonal gammopathy of unknown significance [MGUS], smoldering multiple myeloma [SMM], multiple myeloma [MM]). Recommended at initial diagnosis and/or at disease progression. Refer to companion test FISH, Interphase, CD138+ Cells for custom FISH probe ordering to monitor for a previously identified clone.
3 mL bone marrow to a Green (Sodium Heparin). (Min: 1 mL)
- Sample collection: Non-diluted bone marrow aspirate. Collect in a sodium heparinized Vacutainer.
- Specimen preparation: Do not freeze or expose to extreme temperatures.
- Bone Marrow: Transfer 3 mL bone marrow to a Green (Sodium Heparin). (Min: 1 mL)
- Whole Blood: Transport 5 mL whole blood. (Min: 2 mL)
- Storage/Transport Temperature: Room temperature.
- Unacceptable Conditions: Frozen specimens. Clotted specimens.
- Remarks:
- Stability: Ambient: 48 hours; Refrigerated: 48 hours; Frozen: Unacceptable
Fluorescence in situ Hybridization (FISH)
Sample received to report Turnaround time (TAT)
5 working days
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Interpretive Data
Probes include: IGH break-apart, t(4:14) FGFR3/IGH, t(11:14) CCND1/IGH, t(14:16) IGH/MAF, Hyperdiploidy (Chr 5, 9, 15), TP53/17p del, 13q del (DLEU/LAMP1), del(1p32)/dup(1q21) CDKN2C/CKS1B, (8;14) MYC/IGH, t(14:20) IGH/MAFB
The most recent WHO classification of Tumours of Hematopoietic and Lymphoid Tissues (Revised 5th edition) is used for interpretation criteria for evaluation.
Resources
- Additional Technical Information
- Test Request Form
Sample Reports
- Enhanced Report
- See report